Standard of Care

Symptoms and Treatments

Lupus symptoms vary widely from one person to another; therefore, the best treatment is decided individually by your physician according to your specific condition.

There are several drug categories such as:

Steroid Therapy First-line treatment in patients with mild and moderate/severe SLE and Lupus Nephritis (LN)
Antimalarial Therapy First-line, add-on, mainstay treatment for patients with SLE and patients with LN
Immunosuppressive Therapies
Methotrexate Mainly used as second-line and beyond treatment in patients with inflammatory arthritis and skin manifestations
Azathioprine Mainly used at second-line and beyond treatment of patients with SLE or LN
Mycophenolate Mofetil Mostly used for induction and/or maintenance therapy for patients with LN. Also used as first- or second-line and beyond therapy for patients with moderate/severe SLE
Also used as third-line and beyond therapy for patients with mild SLE
Cyclophosphamide Mainly used in patients with LN
Primary use is for induction therapy or maintenance therapy for those patients that have not responded to other treatments
Calcineurin Inhibitors (cyclosporine, tacrolimus) Mainly used as third-line and beyond of treatment in patients with mild or moderate/severe SLE and LN
Mainly used as alternative therapies to mycophenolate mofetil
Can be used for induction therapy in refractory patients with LN
Biological Therapies
Rituxan Mainly used at third-line and beyond treatment in patients with moderate/severe SLE and patients with LN
Benlysta Add-on therapy in adult patients with active, autoantibody-positive SLE with a high degree of disease activity despite standard therapy
Used as a third-line and beyond treatment for patients with moderate/severe SLE
Used in a very small number of patients with mild SLE or LN

Usually the treatment plan is based on your age, symptoms, organ involvement stage, and general health. The goals of a treatment plan are to reduce inflammation, reduce organ damage, suppress the over-activity of your immune system, prevent flares, and relieve your symptoms.

In many cases it will take some time (several months or even years) to reach the best treatment for your specific condition and keep your lupus under control. Therefore early diagnosis is crucial to protect your health.